Additionally, it appears that otx2 does not affect the rudimentary lens formation which is seen in loss-of-function rx3 mutants, i.e., eyeless mutants. In mouse, Drosophila and intermediate species otd/Otx genes have shown a remarkable similarity in expression pattern suggesting that they could be part of a conserved control system operating in the brain and different from that coded by the HOX complexes controlling the hindbrain and spinal cord. Moreover, it was observed that rx3, while involved in RPE pigmentation, does not contribute to choroid fissure closure. 10. Furthermore, it was also observed that additional knockdown of otx1b using morpholinos worsened the coloboma phenotype. It was observed that while the otx2 loss-of-function mutant, otx2hu3237 displayed small colobomas and the otx1a mutant, otx1a6del, did not exhibit any morphological eye defects, zebrafish possessing both mutations presented with a range of colobomas, some of which were more severe than otx2 single mutants and the size of the coloboma corresponded with the gene dosage of otx1a. In these organisms, the Otx function is associated to cell movements involved in the. The Otx2 gene encodes a transcription factor essential for the normal development of brain, cerebellum, pineal gland, and eye. In this study, the roles of the zebrafish Otx genes, otx2 and otx1a, as well as the Rx family gene, rx3, in choroid fissure closure, the disruption of which leads to the onset of colobomas, were studied. An Otx related gene is present already in Cnidarians, primitive metazoans with a defined body plan and radial symmetry. In particular, Otx2 seems to play a crucial role in the early. P Otx genes are required for tissue specification in the developing eye. Colobomas are a type of eye defect characterized by the presence of a hole in certain eye structures. Other homeobox gene families, including the Otx and Emx genes, control brain development. Loss of murine Otx2 function due to a homozygous genetic mutation is associated.
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